Chronic Fatigue Syndrome is complex, leaving most doctors and patients puzzled when it comes to treating it. Dr. Kellman specializes in complex, unexplained symptoms, getting down to the root of the condition.
Tired in a way sleep doesn’t fix?
You’re not alone. Many of Dr. Kellman’s patients arrive after years of unexplained symptoms and being told their labs look normal. His job is to keep looking.
The exhaustion of CFS is not resolved by rest and is frequently worsened by exertion. It arrives with unrefreshing sleep, cognitive impairment, pain, and orthostatic symptoms.
Because no single test confirms it, patients are often told nothing is wrong. Many arrive at Dr. Kellman's practice after years of that.
Dr. Kellman treats CFS as a problem of cellular energy production and chronic immune activation rather than a diagnosis of exclusion.
Testing examines mitochondrial function, inflammatory markers, the microbiome, thyroid status, persistent infection, and toxic burden. Treatment addresses the specific drivers found, often combining IV therapy, targeted nutrients, and microbiome repair.
Ongoing fatigue often has more than one driver, and several are treatable. An evaluation can look at:
Care starts with a detailed history and testing chosen around it. Treatment addresses what is found and may combine targeted nutrients, microbiome support, thyroid care when indicated, and in-office therapies such as IV therapy. Patients are seen in Midtown Manhattan and by telehealth.

Everyone gets tired. It's worth seeing a doctor when fatigue lasts more than a few weeks, doesn't improve with rest, gets worse after activity, or comes with other symptoms such as weight change, brain fog, pain or digestive problems. Persistent fatigue often has an identifiable and treatable cause.
No. It has measurable physiological correlates — mitochondrial dysfunction, immune activation, and microbiome disruption among them. Dr. Kellman's workup looks for those drivers directly.
Beyond standard bloodwork: mitochondrial and metabolic markers, inflammatory markers, precise thyroid testing, microbiome analysis, screening for persistent infection, and toxic exposure assessment. The pattern across them is what directs treatment.
Yes. Fatigue is one of the most common symptoms of low thyroid, which is why thyroid testing is part of a fatigue evaluation. Other causes, such as anemia or sleep apnea, can look similar and are checked too.
Primary care and internal medicine doctors usually start the evaluation, and specialists may be involved depending on the cause. Dr. Kellman, an internist practicing functional medicine, focuses on patients whose fatigue has continued without a clear explanation.
Fatigue is a symptom with many possible causes. Chronic fatigue syndrome (ME/CFS) is a specific condition with fatigue lasting six months or more, worsening after exertion, unrefreshing sleep and cognitive or orthostatic symptoms.
Yes. Post-viral fatigue, including after COVID, is a common reason patients come in. See also our long-haul COVID page.
“Dr. Kellman is one of the first doctors to truly listen to what I am going through and help me get to the root cause of problems.”
Google review · Jun 2023
“I was exhausted all the time and often felt sick, but did not know why. Dr.Kellman helped me tremendously. I have my energy back and I am feeling healthier than I felt in a long time.”
Google review · Dec 2023
“Dr. Kellman’s knowledge is unprecedented. He is a brilliant and compassionate doctor and has helped me tremendously over the years.”
Google review · May 2026
Reviews are shared exactly as written by patients on Google. Individual experiences vary.